Application of Artificial Intelligence in Healthcare

This workshop will introduce you to the concepts of big data, Artificial Intelligence (AI) and Machine Learning (ML) and their application in health care.

author

Zhenyuan Lu

where

Tufts University, Boston, MA

given

reading time

2 min

Contents
  1. HIA Immersion Weekend Jan 8th, 2021
  2. Workshop 3: Introduction to Application of Artificial Intelligence in Healthcare
  3. DeepVariant
  4. End-to-end lung cancer screening
  5. DeepMind
  6. References
A small neural network: three red input nodes, two layers of four blue nodes and one green output node, which gives p(He’s flirting) = 0.9 and p(Just saying Hi) = 0.1.

HIA Immersion Weekend Jan 8th, 2021

Workshop 3: Introduction to Application of Artificial Intelligence in Healthcare

The workshop will introduce you to the concepts of big data, Artificial Intelligence (AI) and Machine Learning (ML) and their application in health care. You will also explore the application of the most important types of ML methods- supervised and unsupervised through various use cases in health care including medical diagnosis, disease management, screening and clinical decision support.

DeepVariant

How DeepVariant is improving the accuracy of genomic analysis

Sequencing genomes enables us to identify variants in a person’s DNA that indicate genetic disorders such as an elevated risk for breast cancer. DeepVariant is an open-source variant caller that uses a deep neural network to call genetic variants from next-generation DNA sequencing data. [1]

End-to-end lung cancer screening

A promising step forward for predicting lung cancer

Radiologists typically look through hundreds of 2D images within a single CT scan and cancer can be miniscule and hard to spot. We created a model that can not only generate the overall lung cancer malignancy prediction (viewed in 3D volume) but also identify subtle malignant tissue in the lungs (lung nodules). The model can also factor in information from previous scans, useful in predicting lung cancer risk because the growth rate of suspicious lung nodules can be indicative of malignancy. [2]

This is a high level modeling framework. For each patient, the AI uses the current CT scan and, if available, a previous CT scan as input. The model outputs an overall malignancy prediction. https://blog.google/technology/health/lung-cancer-prediction/.

DeepMind

According to google initial findings [3], which have been published in Nature. These findings show that our AI model spotted breast cancer in de-identified screening mammograms (where identifiable information has been removed) with greater accuracy, fewer false positives, and fewer false negatives than experts.

This is a visualization of tumor growth and metastatic spread in breast cancer. Screening aims to detect breast cancer early, before symptoms develop. https://blog.google/technology/health/improving-breast-cancer-screening/.

References

  1. 1A universal SNP and small-indel variant caller using deep neural networksRyan Poplin, Pi-Chuan Chang, David Alexander, Scott Schwartz, Thomas Colthurst, Alexander Ku, Dan Newburger, Jojo Dijamco, Nam Nguyen, Pegah T Afshar, Sam S Gross, Lizzie Dorfman, Cory Y McLean, Mark A DePristoNature Biotechnology, 2018 · doi.org
  2. 2End-to-end lung cancer screening with three-dimensional deep learning on low-dose chest computed tomographyDiego Ardila, Atilla P. Kiraly, Sujeeth Bharadwaj, Bokyung Choi, Joshua J. Reicher, Lily Peng, Daniel Tse, Mozziyar Etemadi, Wenxing Ye, Greg Corrado, David P. Naidich, Shravya ShettyNature Medicine, 2019 · doi.org
  3. 3International evaluation of an AI system for breast cancer screeningScott Mayer McKinney, Marcin Sieniek, Varun Godbole, Jonathan Godwin, Natasha Antropova, Hutan Ashrafian, Trevor Back, Mary Chesus, Greg S. Corrado, Ara Darzi, Mozziyar Etemadi, Florencia Garcia-Vicente, Fiona J. Gilbert, Mark Halling-Brown, Demis Hassabis, Sunny Jansen, Alan Karthikesalingam, Christopher J. Kelly, Dominic King, Joseph R. Ledsam, David Melnick, Hormuz Mostofi, Lily Peng, Joshua Jay Reicher, Bernardino Romera-Paredes, Richard Sidebottom, Mustafa Suleyman, Daniel Tse, Kenneth C. Young, Jeffrey De Fauw, Shravya ShettyNature, 2020 · doi.org